Davao De Oro is home to small, medium, and large high school, namely:
- Alimadmad Integrated School
- Andap National High School
- Andili National High School
- Anibongan National High School
- Anitapan National High School
- Araibo National High School
- Atty. Orlando S. Rimando National High School
- Awao National High School
- Babag National High School
- Bahi National High School
- Bango National High School
- Bango National High School
- Bantacan National High School
- Bayabas National High School
- Belmonte Integrated School
- Bongabong National High School
- Bongkilaton Integrated School
- Boringot National High School
- Boringot National High School
- Cabangkalan Integrated School
- Cabidianan National High School
- Cagan National High School
- Camanlangan National High School
- Camansi National High School
- Canidkid Integrated School
- Casoon National High School
- Cogonon Integrated School
- Compostela National High School
- Compostela National High School
- Consuelo M. Valderrama National High School
- Consuelo M. Valderrama National High School
- Corazon C. Aquino National High School
- Corazon C. Aquino National High School
- Danggayon Integrated School
- Datu Davao National High School
- Depot An Central Domain National High School
- Diosdado Macapagal National High School
- Diosdado Macapagal National High School
- Don Vicente Romualdez National High School
- Elizalde National High School
- Gabi National High School
- Gabi National High School
- Golden Valley National High School
- Kaligutan Integrated School
- Kao National High School
- Kapatagan National High School
- Katipunan Integrated School
- Kidawa National High School
- Kilagding National High School
- Laak National High School
- Lawaan National High School
- Libaylibay National High School
- Longanapan Integrated School
- Lorenzo S. Sarmiento Sr. National High School
- Mabini National High School
- Mabuhay National High School
- Magangit Integrated School
- Magcagong National High School
- Magnaga National High School
- Magsaysay National High School
- Mainit National High School
- Major Angel V. Fajardo National High School
- Manat National High School
- Mangayon National High School
- Mangayon National High School
- Manurigao Integrated School
- Maparat National High School
- Maparat National High School
- Mayaon National High School
- Melale National High School
- Monkayo National High School
- Montevista National High School
- Nabunturan National Comprehensive High School
- Napnapan National High School
- New Bataan National High School
- New Kapatagan National High School
- New Leyte National High School
- New Panay Integrated School
- New Sibonga National High School
- New Visayas National High School
- Nuevo Iloco National High School
- Olaycon Integrated School
- Panansalan Integrated School
- Pangi National High School
- Panibasan National High School
- Pantukan National High School
- Parasanon Integrated School
- Pasian National High School
- Pindasan National High School
- Pongpong Integrated School
- San Antonio National High School
- San Isidro Integrated School
- San Miguel National High School
- San Miguel National High School
- San Vicente Integrated School
- Siocon National High School
- Siocon National High School
- Tagugpo National High School
- Tambongon National High School
- Tan-awan Integrated School
- Tandawan Integrated School
- Teresa National High School
- Tuboran National High School
- Tubo-Tubo National High School
- ULIP NATIONAL HIGH School
- Union National High School
- Union National High School Mt. Diwata HS Annex
