Mati City is home to many high school institutions, namely:
- Mati National Comprehensive High School (MNCHS)
- Bobon National High School
- Buso National High School
- Dawan National High School
- Don Enrique Lopez National High School
- Libudon National High School
- Mati School of Arts and Trade
- Matiao National High School
- Davao Oriental Regional Science High School
- Taguibo Agricultural Vocational High School
- Don Salvador Lopez National High School
- Lawigan National High School
- Badas High School
- Mayo National High School